The Silver Proof Sets entered their second decade from 2000 to 2009 and established themselves as a mainstay within the US Mint's product line up. The inclusion of five 90% silver State Quarters continued until the end of the series in 2008. Several new series and coin designs were introduced during this time for some of the non-silver denominations. In 2009, a new quarter series was launched, which would cause the inclusion of another silver coin in the set.
From 2000 to 2008, the Silver Proof Sets continued to be packaged in the packaging established in the prior year with the launch of the State Quarter series. This included coins sealed in plastic lenses and packaged in a cardboard box bearing an image of the Statue of Liberty under a red color scheme. In 2007, the number of lenses included in the proof set was increased to accommodate the Presidential Dollar series, although the basic design remained the same.
During this time period, there were a number of coins launched or relaunched with multiple designs. All of these new coins introduced were not produced in 90% silver for the sets. This included the Sacagwea Dollar introduced in 2000, the Westward Journey Jefferson Nickels issued from 2004 to 2005, and the Presidential Dollar series launched in 2007.
In 2009, the Silver Proof Set saw a change to its silver coins when the District of Columbia and United States Territories Quarters Program launched. This set included six different quarter designs, which finally boosted the number of 90% silver coins in the set by one. This year also included four redesigned Lincoln Cents, which were included in a separate lens. The overall packaging of the set was also changed with a fresh design for the outer cardboard box and lens inserts.
